For years, GLP-1 medications like Semaglutide and Tirzepatide have been hailed as revolutionary tools for weight loss and type 2 diabetes management. But emerging research is now highlighting another powerful benefit: the ability of these medications to improve — and even reverse — fatty liver disease.
Fatty liver disease, also known as non-alcoholic fatty liver disease (NAFLD) or its more severe form, non-alcoholic steatohepatitis (NASH), affects millions globally and has long been considered difficult to treat. It’s closely tied to obesity, insulin resistance, and metabolic syndrome. Until recently, there was no FDA-approved medication specifically for treating it. Now, GLP-1 receptor agonists are changing the game.
How GLP-1s Help the Liver
GLP-1 medications work by mimicking the body’s natural incretin hormones, which help regulate blood sugar, slow gastric emptying, and suppress appetite — all of which lead to weight loss. But studies have now shown that these effects also reduce liver fat, inflammation, and fibrosis — the key drivers of fatty liver disease progression.
In clinical trials, patients taking GLP-1s like Semaglutide and Tirzepatide showed significant reductions in liver fat content, even without drastic changes in diet or exercise. Some participants even saw complete resolution of NASH — a groundbreaking milestone for a condition that previously relied only on lifestyle changes.
Compounded GLP-1s: Accessible and Effective
While name-brand GLP-1s like Ozempic or Zepbound can be expensive or in short supply, compounded versions offer a more accessible and cost-effective alternative. Compounded Semaglutide and Tirzepatide are made by licensed pharmacies using the same active ingredients, offering similar weight loss and metabolic benefits — including support for liver health.
For patients struggling with both obesity and fatty liver, compounded GLP-1 medications may offer dual benefits: sustainable weight loss and liver protection.
If you’ve been diagnosed with fatty liver disease — or are at risk — it may be time to speak to your provider about GLP-1 treatment options. Not only can they help you lose weight and improve your overall metabolic health, but they may also protect your liver in ways we’re just beginning to understand.
At KYO, we offer compounded GLP-1 medications prescribed through licensed providers, shipped discreetly to your door. Whether your goal is weight loss, blood sugar control, or liver health — we’re here to support your journey with affordable, science-backed care.